Yasuki Higashimura Selected Research

Inflammation (Inflammations)

1/2024	D-alanine inhibits murine intestinal inflammation by suppressing IL-12 and IL-23 production in macrophages.
11/2021	Dietary intake of yacon roots (Smallanthus sonchifolius) affects gut microbiota and fecal mucin and prevents intestinal inflammation in mice.
1/2021	Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats.
7/2020	Zinc Deficiency Activates the IL-23/Th17 Axis to Aggravate Experimental Colitis in Mice.
1/2020	Trans-unsaturated fatty acid activates NLRP3 inflammasome in macrophages and exacerbates intestinal inflammation in mice.
1/2019	Elevated ER stress exacerbates dextran sulfate sodium-induced colitis in PRDX4-knockout mice.
3/2018	Secreted protein acidic and rich in cysteine functions in colitis via IL17A regulation in mucosal CD4+ T cells.
1/2018	Lactobacillus brevis KB290 With Vitamin A Ameliorates Murine Intestinal Inflammation Associated With the Increase of CD11c+ Macrophage/CD103- Dendritic Cell Ratio.
10/2016	Partially hydrolysed guar gum ameliorates murine intestinal inflammation in association with modulating luminal microbiota and SCFA.
8/2013	Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxygenase-1 expression.

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Yasuki Higashimura Research Topics

Disease

12	Colitis 01/2024 - 03/2013
11	Inflammation (Inflammations) 01/2024 - 03/2013
6	Neoplasms (Cancer) 05/2022 - 01/2011
5	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 07/2020 - 03/2013
5	Hypoxia (Hypoxemia) 01/2016 - 01/2010
2	Body Weight (Weight, Body) 05/2021 - 01/2019
2	Intestinal Diseases (Diseases, Intestinal) 05/2021 - 12/2017
2	Non-alcoholic Fatty Liver Disease 05/2021 - 07/2019
2	Ulcer 01/2021 - 02/2014
2	Type 2 Diabetes Mellitus (MODY) 03/2020 - 01/2019
2	Dysbiosis 07/2019 - 03/2016
2	Carcinogenesis 03/2018 - 03/2016
2	Breast Neoplasms (Breast Cancer) 01/2016 - 05/2011
2	Prostatic Neoplasms (Prostate Cancer) 01/2011 - 08/2007
1	Ulcerative Colitis 01/2024
1	Cachexia 05/2022
1	Paralysis (Palsy) 03/2022
1	Alzheimer Disease (Alzheimer's Disease) 03/2022
1	Food Hypersensitivity (Food Allergy) 01/2022
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 05/2021
1	COVID-19 01/2021
1	Crohn Disease (Crohn's Disease) 07/2020
1	Dyslipidemias (Dyslipidemia) 03/2020
1	Fatty Liver 07/2019
1	Insulin Resistance 01/2019
1	Colorectal Neoplasms (Colorectal Cancer) 11/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2018
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 07/2016
1	Stomach Ulcer (Gastric Ulcer) 07/2016

Drug/Important Bio-Agent (IBA)

6	Sulfonic AcidsIBA 11/2021 - 08/2013
5	sym-trinitrobenzeneIBA 11/2021 - 08/2013
5	Peroxidase (Myeloperoxidase)IBA 05/2021 - 02/2014
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2011
4	Bile Acids and Salts (Bile Acids)IBA 07/2021 - 03/2016
3	guar gum (guaran)IBA 05/2022 - 10/2016
3	Messenger RNA (mRNA)IBA 05/2021 - 10/2016
3	Therapeutic UsesIBA 01/2021 - 08/2013
2	Dextran SulfateIBA 01/2024 - 01/2019
2	Dietary Fiber FDA Link 05/2022 - 05/2021
2	betaninIBA 03/2022 - 01/2019
2	MucinsIBA 11/2021 - 12/2017
2	Volatile Fatty AcidsIBA 05/2021 - 03/2016
2	Carbon MonoxideIBA 01/2021 - 10/2016
2	ZincIBA 07/2020 - 07/2016
2	Phenobarbital (Luminal)FDA Link 07/2019 - 10/2016
2	Biomarkers (Surrogate Marker)IBA 06/2017 - 10/2016
2	OligosaccharidesIBA 03/2016 - 08/2013
2	Transcription Factors (Transcription Factor)IBA 01/2016 - 01/2011
2	Indomethacin (Indometacin)FDA LinkGeneric 02/2014 - 04/2013
2	Heme Oxygenase-1IBA 08/2013 - 03/2013
2	Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)IBA 05/2011 - 08/2007
2	DNA (Deoxyribonucleic Acid)IBA 01/2011 - 01/2010
2	LigandsIBA 01/2011 - 08/2007
2	Androgen Receptors (Androgen Receptor)IBA 01/2011 - 08/2007
1	Amino Acids FDA Link 01/2024
1	Alanine (L-Alanine)FDA Link 01/2024
1	Interleukin-12 (IL 12)IBA 01/2024
1	Interleukin-23 (Interleukin 23)IBA 01/2024
1	Interleukin-23 Subunit p19IBA 01/2024
1	Interleukin-12 Subunit p35IBA 01/2024
1	BetalainsIBA 03/2022
1	Amyloid (Amyloid Fibrils)IBA 03/2022
1	AntioxidantsIBA 03/2022
1	LycopeneIBA 01/2022
1	EndotoxinsIBA 05/2021
1	Nonesterified Fatty Acids (NEFA)IBA 05/2021
1	Glucose (Dextrose)FDA LinkGeneric 05/2021
1	PrebioticsIBA 05/2021
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 05/2021
1	CholesterolIBA 05/2021
1	Alanine Transaminase (SGPT)IBA 05/2021
1	Triglycerides (Triacylglycerol)IBA 05/2021
1	Thiobarbituric Acid Reactive SubstancesIBA 01/2021
1	SolutionsIBA 01/2021
1	rho-Associated KinasesIBA 01/2021
1	AcidsIBA 07/2020
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2020
1	Trans Fatty AcidsIBA 01/2020
1	elaidic acidIBA 01/2020
1	InflammasomesIBA 01/2020
1	TeaIBA 07/2019
1	Catechin (Z 7300)IBA 07/2019
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 07/2019
1	PolyphenolsIBA 07/2019
1	Taurine FDA Link 07/2019
1	LipidsIBA 01/2019
1	Insulin (Novolin)FDA Link 01/2019
1	Drinking WaterIBA 01/2019
1	Dipeptidyl-Peptidase IV InhibitorsIBA 01/2019
1	Peptides (Polypeptides)IBA 11/2018
1	Cysteine (L-Cysteine)FDA Link 03/2018
1	Carotenoids (Carotene)IBA 01/2018
1	Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric 01/2018
1	Vitamin A (Retinol)FDA LinkGeneric 01/2018
1	polaprezinc (Z 103)IBA 07/2016

Therapy/Procedure

3	Therapeutics 01/2019 - 01/2011
1	Intraperitoneal Injections 01/2024
1	Enema (Enemas) 01/2021
1	Rectal Administration 01/2021
1	Secondary Prevention 01/2018